Analyses of spike protein from first deposited sequences of SARS-CoV2 from West Bengal, India

India has recently started sequencing SARS-CoV2 genome from clinical isolates. Currently only few sequences are available three states in India. Kerala was the first state to deposit complete sequence two isolates followed by one Gujarat. On April 27, 2020, five of West Bengal (Eastern India) were deposited on GISAID, a global initiative for sharing avian flu data. In this study, we have analysed spike protein all and also compared their similarities or differences with other reported India Wuhan origin. We report unique mutation at position 723 another 1124 S2 domain only. There downstream receptor binding 614 S1 which common Gujarat (a western India). Mutation showed changes secondary structure region mutation. studied molecular dynamics using normal mode analyses found that decreases flexibility domain. Since both important entry host cells, such mutations may define affinity avidity binding.